This Mississippi pot roast recipe delivers tender, juicy beef infused with tangy peperoncini and herbs, all while keeping it naturally gluten-free and low-carb. It’s rich in flavor, falls apart with the touch of a fork, and is packed with protein to keep you satisfied for hours.

We developed this recipe to maximize flavor while sticking to a wholesome, nutrition-focused approach. By using simple swaps like coconut aminos instead of overly processed ingredients and allowing slow cooking to draw out all the natural goodness of the beef, this dish checks every box for health-conscious home cooks. Prepare to enjoy comfort food that fits your wellness goals!

Why This Mississippi Pot Roast Recipe Is Good for You

High in Protein: One serving provides 36 grams of protein to fuel your muscles and promote satiety.
Low in Carbs: With only 3 grams of carbs per serving, it’s perfect for keto and low-carb diets.
Rich in Healthy Fats: The balance of healthy fats keeps this dish creamy and satisfying without being heavy.
Gluten-Free: This recipe skips processed seasoning packets, making it naturally gluten-free for those with sensitivities.
Whole Ingredients: Each component is minimally processed and packed with nutrients, like the vitamin C in peperoncinis.

Wholesome Ingredients for This Mississippi Pot Roast Recipe

Every ingredient in this recipe has been carefully chosen for both its nutritional value and ability to pack a punch of flavor. Here are some highlights:

Beef Chuck Roast: A classic cut for slow cooking, it’s rich in protein and becomes ultra-tender after hours in the slow cooker. Look for grass-fed beef for higher omega-3 content.
Coconut Aminos: This soy sauce alternative is naturally lower in sodium and free from gluten, making it a nutrient-dense flavor booster.
Peperoncini: These tangy peppers not only add a bright, zesty kick but also bring a dose of vitamin C to the dish.
Homemade Herb Blend: Garlic powder, onion powder, parsley, and dill create layers of flavor without relying on processed seasonings. Try fresh herbs for a more vibrant taste if you have them on hand.

Mississippi Pot Roast Recipe at a Glance

Servings: 8 servings
Prep Time: 10 minutes
Cook Time: 8 hours
Total Time: 8 hours, 10 minutes

Mississippi Pot Roast Recipe Ingredients

2 ½– to 3-lb beef chuck roast
2 tablespoons butter, softened
1 teaspoon garlic powder
1 teaspoon onion powder
1 teaspoon fine salt
1 teaspoon dried parsley
1 teaspoon dried dill
1 cup beef broth
3 tablespoons coconut aminos
¼ cup peperoncini juice (from the jar of peperoncinis)
12 jarred whole peperoncinis

How to Make Mississippi Pot Roast Recipe

Pat the beef chuck roast dry using a paper towel to ensure a good texture during cooking.
Place the roast in your slow cooker.
In a small bowl, mash together the softened butter, garlic powder, onion powder, salt, parsley, and dill until well combined.
Spread the butter mixture evenly over the top of the roast with a spatula or your hands.
Pour the beef broth, coconut aminos, and peperoncini juice around the roast.
Top the roast with the jarred peperoncinis, arranging them evenly.
Cover the slow cooker with the lid and set it to cook on low heat for 8-10 hours (or on high heat for 4-6 hours if needed).
Once done, use two forks to shred the beef into tender pieces directly in the slow cooker.
Toss the shredded beef with the surrounding juices and peperoncinis to distribute the flavor evenly. Serve warm and enjoy!

How to Customize This Mississippi Pot Roast Recipe for Your Diet

Keto Friendly: This recipe is naturally keto! For additional fat, add a drizzle of olive oil before serving.
Dairy-Free: Switch out the butter for a plant-based alternative like coconut oil or vegan butter.
Low Sodium: Use low-sodium beef broth and adjust seasonings to taste.
Paleo: Double-check your coconut aminos for added sugars and opt for a compliant brand if necessary.

Our Team’s Tips for the Best Mississippi Pot Roast Recipe

For the juiciest roast: Always cook on the low heat setting unless you’re short on time.
Season generously: Don’t be shy with the herb butter—it’s what makes each bite unforgettable.
Batch cooking: Freeze leftovers in airtight containers for easy, healthy meals during busy weeks.
Reheat smarter: Warm in a covered skillet with reserved juices to keep the meat moist.

Mississippi Pot Roast Recipe FAQs

Can I make this in an instant pot instead of a slow cooker?

Yes! Use the sauté function to sear the roast first, then pressure cook on high for 60 minutes followed by a natural release.

How can I add more vegetables to this recipe?

Add hearty root vegetables like carrots and parsnips to the slow cooker during the last 3 hours of cooking.

We’re excited for you to try this Mississippi pot roast recipe! What health-focused twists do you plan to add? Let us know in the comments!